Scientists are raising the alarm over the potential health risks posed by so-called “mirror bacteria,” artificial organisms with molecular structures opposite to those of current life forms. Researchers have coined the term “mirror” because these bacteria have molecules that mirror the structure of conventional life, similar to left and right hands. This fundamental difference could pose threats to humans, animals, and plants.
The development of synthetic bacteria is still in its nascent stages, with experts predicting that a fully functional mirror bacterium could emerge more than a decade from now. A recent study in the journal Science concluded that creating such organisms should be avoided due to their potential danger.
Molecules—including those forming proteins and DNA—possess a configuration called chirality, which determines their function and structure. While naturally occurring DNA and RNA in Earth’s life forms are “right-handed,” proteins are primarily “left-handed.” A molecule’s chirality affects interactions with other molecules—a concept illustrated by the drug thalidomide, which exists in two forms with vastly different effects.
Current research aims to construct bacteria featuring mirrored molecular chirality, such as left-handed DNA paired with right-handed proteins. This has left the scientific community concerned that mirror bacteria might evade immune responses that rely on chiral recognition, potentially rendering animals and plants defenseless against infection.
Researchers emphasize that these organisms could evade natural predators within ecosystems, leading to unchecked reproduction. In the worst-case scenario, they could act as invasive species, lethally infecting various life forms on Earth, including humans.
To mitigate these risks, researchers suggest imposing strict limitations on advancing studies aimed at creating mirror organisms. If research cannot be halted, experts suggest developing systems to manage and contain these bacteria, preventing widespread damage.
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