The FBI is conducting an ongoing review of fresh biological and DNA evidence collected in the disappearance of Nancy Guthrie, the 84-year-old mother of NBC anchor Savannah Guthrie. The elder Guthrie disappeared from her Tucson home in the early morning hours of February 1 after a suspected abduction.
According to a report from Fox News, investigators have collected DNA samples, including hair, from Guthrie’s Catalonia Foothills home and are currently analyzing it. The samples are expected to undergo more advanced testing with next generation technology.
Additional samples were obtained from a glove discovered approximately two miles from the property.
Investigators initially submitted the DNA profiles to the FBI’s Combined DNA Index System (CODIS), the national database of genetic records from convicted offenders and certain arrestees, but no matches were returned. In response, authorities have pursued investigative genetic genealogy (IGG), a technique that compares crime-scene DNA to public genealogy databases to identify familial connections and narrow potential suspects.
Some of the DNA recovered from the home consists of mixed profiles, meaning genetic material from more than one individual is present.

Savannah Guthrie (left) with her mother, Nancy
CeCe Moore, a leading investigative genetic genealogist at Parabon Nanolabs, told Fox News that a hair sample is unlikely to be one of the samples investigators are struggling to process. “Not after it is cleaned for contamination,” she said. “They have that process in good shape, but it can take some time.”
A Pima County Sheriff’s Department (PCSD) spokesperson indicated that they have been “sharing a lot of things” with the FBI lab since the beginning of the Guthrie investigation.
“PCSD has worked with the FBI since the beginning of the Guthrie investigation. This is not new information,” the department wrote on X. “The private lab we utilize in Florida continues to share information with the FBI lab & other partner labs across the country. DNA analysis remains ongoing.”
Guthrie, 84, was last seen the evening of January 31 when she was dropped off by her son-in-law around 9:50 p.m. local time. Family members reported her missing the following morning after she failed to appear for a scheduled church function.
Investigators uncovered blood and other DNA evidence from the property and have long stated that Guthrie was likely abducted against her will. Recovered surveillance footage from a disabled doorbell camera shows a masked individual wearing a backpack approaching the door before disabling the camera.
Leads were pursued, but investigators have yet to make an arrest in the case, nor have they named any potential suspects.
Multiple ransom notes demanding cryptocurrency payments were also received by media outlets, though one individual was arrested for sending a false note unrelated to the case. The family, including Savannah Guthrie and her siblings, have been cleared as suspects and are cooperating with the investigation.

